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首页 >  新闻动态 >  阿拉丁核酸合成试剂

阿拉丁核酸合成试剂

发布时间:2020-06-23

阿拉丁核酸合成试剂

      寡核苷酸是短的、单链或双链的DNA或RNA分子。其合成方法发展历程:从Michelson和Todd早期的H-磷酸盐和磷酸三酯法(H-Phosphonate & Phosphotriester);到1950年代Khorana的磷酸二酯法(Phosphodiester);以及1960-1970年代的磷酸三酯法(Phosphotriester)和亚磷酸三酯法(Phosphite triester)的发展。而直至1980年代,Marvin Caruthers的亚磷酰胺法(Phosphoramidite),加上自动化固相技术,成为了目前主流的寡核苷酸合成技术方法。在聚合酶链反应(PCR)、核酸测序、基因检测、核酸药物研发等领域有广泛应用。

      亚磷酰胺寡聚体的合成在3'-5'方向进行(与生物合成中DNA复制的5'-3'方向相反)。每个合成周期添加一个核苷酸。亚磷酰胺DNA合成循环如图所示。

 

亚磷酰胺DNA合成循环

保护核苷

产品号中文名称英文名称级别Cas规格
I119475N2-异丁酰基-2′-脱氧鸟苷N2-Isobutyryl-2′-deoxyguanosine98%68892-42-2 100mg,250mg,1g,5g
I1195195'-O-(4,4'-二甲氧基三苯基)-N2-异丁酰基-2'-脱氧鸟苷N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine99.00%68892-41-11g,5g,10g,25g,100g
N159691N6-二苯甲酰基腺苷-2',3'-二苯甲酸酯N6-Dibenzoyladenosine 2',3'-Dibenzoate>98.0%(HPLC)(T)58463-04-0100mg,1g
B119471N4-苯甲酰基-5′-O-(4,4′-二甲氧基三苯基)-2′-脱氧胞苷N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine99%67219-55-01g,5g
B103100N4-苯甲酰胞苷N4-Benzoylcytidine98%13089-48-01g,5g,25g
B119532N4-苯甲酰基-2'-脱氧胞苷N4-Benzoyl-2′-deoxycytidine98.00%4836-13-9250mg,1g,5g
B122954N6-苯甲酰基-2'-脱氧腺苷水合物N6-Benzoyl-2′-deoxyadenosine hydrate98%206752-42-3,4546-72-9250mg,1g,5g
B119470N6-苯甲酰基-5′-O-(4,4′-二甲氧基三苯基)-2′-脱氧腺苷N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine99%64325-78-6100mg,1g,5g
O1176845′-O-(4,4′-二甲氧基三苯甲基)胸苷5′-O-(4,4′-Dimethoxytrityl)thymidine98.00%40615-39-21g,5g,25g
B119477N6-苯甲酰基腺苷N-Benzoyladenosine97%4546-55-81g,5g,25g

核糖,2'-脱氧核糖

产品号中文名称英文名称级别Cas规格
R105972L-核糖L-(+)-Ribose98%24259-59-41g,5g,10g,25g,100g
T107915四乙酰核糖1,2,3,5-Tetra-O-acetyl-β-D-ribofuranose98%13035-61-55g,25g,100g,500g
R104821D-(-)-核糖D-(-)-Ribose≥99%(HPLC)50-69-15g,25g,100g,250g,500g
R104820 D-(-)-核糖D-(-)-Ribose98%50-69-1100g,500g,2.5Kg
R103230 1-乙酰基-2,3,5-三苯甲酰氧基-1-beta-D-呋喃核糖β-D-Ribofuranose 1-acetate 2,3,5-tribenzoate98%6974-32-91g,5g,25g,100g
M158368甲基-β-D-呋喃核糖苷Methyl β-D-Ribofuranoside>97.0%(HPLC)7473-45-21g,5g,25g,100g
D1210773,5-二-O-(对甲苯酰)-2-脱氧-Α-D-呋喃核糖氯3,5-Di-O-(p-toluyl)-2-deoxy-D-ribofuranosyl chloride90%4330-21-6250mg
D104784 2-脱氧-D-核糖2-Deoxy-D-Ribose98%533-67-51g,5g,25g,100g
D1239892-脱氧-2,2-二氟-D-赤-戊糖酸γ-内酯3,5-二苯甲酸酯2-Deoxy-2,2-difluoro-D-erythro-pentonic Acid γ-Lactone 3,5-Dibenzoate98%122111-01-71g,5g,25g,100g
T1394962-脱氧-2-氟-1,3,5-三-O-苯甲酰基-α-D-阿拉伯呋喃糖2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D- arabinofuranose-97614-43-21g,5g,25g

硫转移试剂

产品号中文名称英文名称级别Cas规格
X162986氢化黄原素Xanthane Hydride>95.0%(HPLC)6846-35-15g,25g,100g,500g
H157193 3H-1,2-苯并二硫醇-3-酮1,1-二氧化物3H-1,2-Benzodithiol-3-one 1,1-Dioxide>98.0%(HPLC)66304-01-6250mg,1g,5g
B152485双(苯乙酰)二硫化物Bis(phenylacetyl) Disulfide>98.0%(HPLC)15088-78-55g,25g

磷酸化试剂,磷硫化试剂

产品号中文名称英文名称级别Cas规格
M157887二氯磷酸甲酯Methyl Phosphorodichloridate>95.0%(T)677-24-75g,25g,100g
C1194802-氰乙基N,N,N′,N′-四异丙基亚磷酰二胺2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite97%102691-36-11g,5g,25g,100g
T162687焦磷酸四苄酯Tetrabenzyl Pyrophosphate>98.0%(HPLC)990-91-0250mg,1g,5g,25g
P104277二氯化磷酸苯酯Phenyl dichlorophosphate98%770-12-725g,100g,500g
B152354二(四丁铵)焦磷酸二氢盐Bis(tetrabutylammonium) Dihydrogen Pyrophosphate>96.0%(T)857447-79-150mg,200mg
H157193 3H-1,2-苯并二硫醇-3-酮1,1-二氧化物3H-1,2-Benzodithiol-3-one 1,1-Dioxide>98.0%(HPLC)66304-01-6250mg,1g,5g
C1358752-氯-1,3,2-二氧磷杂环戊烷 2-氧化物2-Chloro-1,3,2-dioxaphospholane-2-oxide≥95.0%6609-64-95g,25g,100g
D156020氯硫代磷酸二乙酯Diethyl Chlorothiophosphate>97.0%(GC)2524-04-15g,25g,100g
C1540112-氯苯基二氯膦酸酯[磷酸化剂]2-Chlorophenyl Phosphorodichloridate [Phosphorylating Agent]>97.0%(T)15074-54-11g,5g,25g,100g
C1540132-氯-4H-1,3,2-苯并二氧磷-4-酮2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one>95.0%5381-99-71g,5g,25g
D109475 氯代磷酸二苯酯Diphenyl phosphoryl chloride97%2524-64-325g,100g,500g
M157888二氯亚磷酸甲酯[亚磷酸化剂]Methyl Dichlorophosphite [Phosphitylating Agent]>95.0%(T)3279-26-35g,10g,25g,100g
B152485双(苯乙酰)二硫化物Bis(phenylacetyl) Disulfide>98.0%(HPLC)15088-78-55g,25g
C1540124-氯苯基二氯磷酸酯4-Chlorophenyl Phosphorodichloridate>97.0%(T)772-79-25g,25g,100g
D110276焦磷酰氯Diphosphoryl chloride97%13498-14-15g,25g,100g,500g
C1537095-氯水杨基-N,N-二异丙基亚磷酰胺5-Chlorosaligenyl-N,N-diisopropylphosphoramidite>95.0%(HPLC)1620086-77-2200mg,1g
C1540142-氯-1,3,2-二氧磷杂环戊烷2-Chloro-1,3,2-dioxaphospholane>97.0%(GC)822-39-95g,25g,100g
D138186N,N-二异丙基亚磷酰胺二叔丁酯Di-tert-butyl N,N-diisopropylphosphoramidite≥95.0%137348-86-81g,5g
D122720 二苄基 N,N-二异丙基亚磷酰胺Dibenzyl N,N-Diisopropylphosphoramidite98%108549-23-11g,5g,25g,100g

缩合剂

产品号中文名称英文名称级别Cas规格
N1328583-硝基-1,2,4-三唑3-Nitro-1,2,4-triazole≥98.0%(HPLC)24807-55-41g,5g,25g,100g
M121621均三甲苯基磺酰氯2-Mesitylenesulfonyl chloride99%773-64-85g,25g,100g,500g
C113337N,N'-羰基二(1,2,4-三氮唑)1,1'-Carbonyl-di-(1,2,4-triazole)96%41864-22-65g,25g,100g
M1356722,4-二磺酰氯基均三甲苯2,4-Mesitylenedisulfonyl Dichloride≥98.0%68985-08-05g,25g
T109597特戊酰氯Trimethylacetyl chloride98%3282-30-225ml,100ml,500ml,2.5L,10L
B1151975-苄硫基四氮唑5-(Benzylthio)-1H-tetrazole98.50%21871-47-65g,25g,100g
D106074N,N'-二环己基碳二亚胺(DCC)N,N′-Dicyclohexylcarbodiimide99.00%538-75-025g,100g,500g,1kg,2.5kg,10kg
C1534191-(氰甲基)哌啶四氟硼酸盐1-(Cyanomethyl)piperidinium Tetrafluoroborate>98.0%(N)434937-12-91g,5g
T1133531-(2,4,6-三异丙基苯基磺酰)咪唑1-(2,4,6-Triisopropylbenzenesulfonyl)imidazole98%50257-40-41g,5g,10g,25g
D1093194,5-二氰基咪唑4,5-Dicyanoimidazole98%1122-28-75g,25g,100g
D1093204,5-二氰基咪唑4,5-Dicyanoimidazole99%1122-28-75g,25g,100g
T1616122,4,5,6-四甲基苯二磺酰二氯2,4,5,6-Tetramethylbenzenedisulfonyl Dichloride>98.0%(T)97997-76-71g,5g
T1389651-(2,4,6-三异丙基苯磺酰)-1,2,4-三唑1-(2,4,6-Triisopropylphenylsulfonyl)-1,2,4-triazole>98.0%(HPLC)54230-60-31g,5g,25g
T1061831-对甲基苯磺酰咪唑1-(p-Toluenesulfonyl)imidazole99%2232-08-85g,25g,100g,500g
T1093412,4,6-三异丙基苯磺酰氯2,4,6-Triisopropylbenzenesulfonyl chloride97%6553-96-45g,25g,100g,500g
D105651N,N'-二环己基-4-吗啉脒N,N′-Dicyclohexyl-4-morpholinecarboxamidine98%4975-73-95g,25g,100g,500g
T1006451,2,4-三氮唑1,2,4-Triazole99%288-88-025g,100g,250g,500g
E1113105-乙硫基四氮唑5-(Ethylthio)-1H-tetrazole98%89797-68-21g,5g,25g,100g

羟基保护剂,氨基保护剂

产品号中文名称英文名称级别Cas规格
I107549异丁酰氯Isobutyryl Chloride98%79-30-125ml,100ml,500ml,2.5L
H106017六甲基二硅胺烷Hexamethyl disilylamineAR,98%999-97-3100ml,500ml,2.5L,10L
D154192二叔丁基二氯硅烷Di-tert-butyldichlorosilane>95.0%(GC)18395-90-91g,5g
N1066032-硝基溴化苄2-Nitrobenzyl bromide97%3958-60-95g,25g,100g
P160117苯氧基乙酰氯Phenoxyacetyl Chloride>98.0%(GC)701-99-525g,100g,500g
B1528961,3-苯并二硫代吡咯四氟化硼盐[羟基保护剂]1,3-Benzodithiolylium Tetrafluoroborate [Hydroxyl-Protecting Agent]>96.0%(T)57842-27-01g,5g
T109041N,O-双(三甲基硅烷基)乙酰胺N,O-Bis(trimethylsilyl)acetamide95%10416-59-825ml,100ml,500ml,5L
T131644 N,O-双(三甲基硅烷基)乙酰胺TMS-BA用于GC衍生化10416-59-85ml,25ml
A108664乙酰氯Acetyl chloride99%,无色75-36-5500ml,2.5L
A108662乙酰氯Acetyl chlorideAR,98%75-36-5100ml,500ml,12*500ml,2.5L,10L
C1349682-氯代三苯甲基氯2-Chlorotrityl Chloride≥97.0%42074-68-025g,100g,500g,2.5kg
T109597特戊酰氯Trimethylacetyl chloride98%3282-30-225ml,100ml,500ml,2.5L,10L
D106289N,N-二甲基甲酰胺二甲缩醛DMF-DMA98%,用于酯化4637-24-525g,100g,500g
D106288N,N-二甲基甲酰胺二甲缩醛N,N-Dimethylformamide Dimethyl Acetal97%4637-24-525ml,100ml,500ml
T106184三苯基氯甲烷Trityl Chloride97%76-83-525g,100g,250g,500g,2.5kg
C153889 4-氯苯氧基乙酰氯4-Chlorophenoxyacetyl Chloride>98.0%(T)4122-68-35g,10g,25g,100g,500g
T1093412,4,6-三异丙基苯磺酰氯2,4,6-Triisopropylbenzenesulfonyl chloride97%6553-96-45g,25g,100g,500g
D1092924,4'-二甲氧基三苯基氯甲烷4,4′-Dimethoxytrityl chloride>97.0%40615-36-95g,25g,100g,500g
D119481二叔丁基硅基双(三氟甲烷磺酸)Di-tert-butylsilyl bis(trifluoromethanesulfonate)97%85272-31-71g,5g,25g
B111191叔丁基二苯基氯硅烷tert-Butyldiphenylchlorosilane98%58479-61-110g,25g,100g,250g
B103644 叔丁基二甲基氯硅烷tert-Butyldimethylsilyl chloride97%18162-48-625g,100g,250g,500g
T1626344,4',4''-三(苯酰氧基)三苯甲基溴[羟基保护剂]4,4',4''-Tris(benzoyloxy)trityl Bromide [Hydroxyl Protecting Agent]>97.0%(T)86610-66-41g,5g,25g
D1135291,3-二氯四甲基二硅氧烷1,3-Dichloro-1,1,3,3-tetramethyldisiloxane95%2401-73-25g,25g,100g
D1391831,3二氯-1,1,3,3-四异丙基二硅氧烷1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane≥97%69304-37-61g,5g,25g,100g
M1006114-甲氧基苯甲酰氯4-Methoxybenzoyl chloride97%100-07-225g,100g,500g
B104566苯甲酰氯Benzoyl chlorideACS, ≥99.0% (T)98-88-4500g
C104814 三甲基氯硅烷(TMCS)Chlorotrimethylsilane≥99.0%(GC)75-77-4100ml,250ml,500ml,2.5L,10L
C104813 三甲基氯硅烷(TMCS)Chlorotrimethylsilane>98.0%(GC)75-77-4100ml,250ml,500ml,2.5L,10L
T106616三氟甲磺酸三甲基硅酯Trimethylsilyl trifluoromethanesulfonate98.00%27607-77-85g,10g,25g,50g,100g,250g,500g
M1135034-甲氧基氯化三苯甲烷4-Monomethoxytrityl chloride97%14470-28-15g,10g,25g,100g,250g
B104818 苯甲酸酐Benzoic anhydride98%93-97-025g,100g,500g

脱保护剂

产品号中文名称英文名称级别Cas规格
T103291三氟乙酸(TFA)Trifluoroacetic acidAR,99.0%76-05-1100g,500g,2.5kg
H107501六氟异丙醇1,1,1,3,3,3-Hexafluoro-2-propanol99.50%920-66-1 25g,100g,250g,500g,2.5kg


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