阿拉丁小分子抑制剂、激动剂、拮抗剂--血管生成信号通路（上）

发表时间：2021-01-29

血管生成

血管生成，即从已存在的血管中生成新血管。此通路是通过人体中存在的诸多互补和复杂的信号途径调节的。正常情况下，血管生成的相关诱导剂和抑制剂之间保持平衡状态。但对于创伤、缺氧或炎症继发等微环境破坏的条件下，此通路能做出迅速的应答。在各种慢性病理和肿瘤的情况下，血管生成的平衡状态被打破，导致异常的血管生成或新生血管。

血管生成信号通路转导过程

血管生成的激活导致促血管生成生长因子（VEGF、PDGF、FGF和TGF等）的释放，这些因子将其受体结合到已有血管内的内皮细胞上，从而诱导PI3K/Akt、Erk1/2、Smad和Notch等多种途径的信号转导，引起内皮细胞增殖和迁移。内皮细胞利用基质金属蛋白酶和整合素来消化细胞外基质，迁移到新的区域，在那里它们延长并形成管子，产生新的血管。
在肿瘤血管生成过程中，癌细胞刺激新血管的形成，为肿瘤输送氧气和营养。随着肿瘤的生长，位于肿瘤中心的细胞缺氧，使得转录因子HIF-1α（缺氧诱导因子-1）稳定表达。该转录因子与HIF-1β结合上调几种促血管生成基因的表达。此外，生长因子信号还刺激HIF-1活性，以维持生长细胞的氧稳态。

血管生成信号通路图

产品列表

*FLT

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki
S129593	Sorafenib Tosylate	≥99%	475207-59-1	50mg,100mg,250mg,1g,5g	无细胞	Raf-1	6 nM
					无细胞	B-Raf	22 nM
						VEGFR-2	90 nM
						VEGFR-3	20 nM
						PDGFR-β	57 nM
						Flt-3	59 nM
						c-KIT	68 nM
T127762	Tozasertib	≥98%	639089-54-6	25mg,100mg		FLT3	30 nM
S125267	SP600125	≥98%	129-56-6	25mg,100mg,500mg,1g,5g	无细胞	JNK1	40 nM
						JNK2	40 nM
						JNK3	90 nM
F127011	Foretinib (GSK1363089)	≥98%	849217-64-7	5mg,25mg,100mg	无细胞	Met	0.4 nM
F127011	Foretinib (GSK1363089)	≥98%	849217-64-7	5mg,25mg,100mg	无细胞	KDR	0.9 nM
Q127558	Quizartinib (AC220)	≥99%	950769-58-1	5mg,10mg,50mg,500mg	MV4-11	Flt3(ITD)	1.1 nM/4.2 nM
Q127558	Quizartinib (AC220)	≥99%	950769-58-1	5mg,10mg,50mg,500mg	RS4;11	Flt3(WT)	1.1 nM/4.2 nM
D126778	Dovitinib (TKI-258, CHIR-258)	≥99%	405169-16-6	10mg,50mg,250mg	无细胞	FLT3	1 nM
D126778	Dovitinib (TKI-258, CHIR-258)	≥99%	405169-16-6	10mg,50mg,250mg	无细胞	c-Kit	2 nM
T126330	Fedratinib (SAR302503, TG101348)	≥98%	936091-26-8	5mg,25mg,100mg	无细胞	JAK2	3 nM
L126993	Linifanib (ABT-869)	≥99%	796967-16-3	5mg,10mg,50mg		KDR	4 nM
						CSF-1R	3 nM
						Flt-1/3	3 nM/4 nM
						PDGFRβ	66 nM
C127776	Crenolanib (CP-868596)	≥99%	670220-88-9	5mg,10mg,50mg		PDGFRα	2.1 nM
C127776	Crenolanib (CP-868596)	≥99%	670220-88-9	5mg,10mg,50mg		PDGFRβ	3.2 nM
R129910	R406 (free base)	≥99%	841290-80-0	5mg,10mg,25mg,50mg,100mg		Syk	41 nM
M127412	Amuvatinib (MP-470)	≥98%	850879-09-3	5mg,25mg,100mg		c-Kit	10 nM
						PDGFα	40 nM
						Flt3	81 nM
T125150	Tandutinib (MLN518)	≥98%	387867-13-2	25mg,100mg,500mg		FLT3	0.22 μM
T127523	TG101209	98%	936091-14-4	5mg,25mg,100mg	无细胞	JAK2	6 nM
						Flt3	25 nM
						RET	17 nM
K127169	KW-2449	≥98%	1000669-72-6	5mg,25mg,100mg		Flt3	6.6 nM
E126318	ENMD-2076	≥99%	934353-76-1	5mg,10mg,50mg		Aurora A	14 nM
E126318	ENMD-2076	≥99%	934353-76-1	5mg,10mg,50mg		Flt3	1.86 nM
L127618	LDK378	≥99%	1032900-25-6	5mg,25mg,100mg,250mg	无细胞	ALK	0.2 nM
						IGF-1R	8 nM
						InsR	7 nM
						STK22D	23 nM
						FLT3	60 nM
P129908	PRT062607 (P505-15, BIIB057) HCl	≥98%	1370261-97-4	5mg,25mg	无细胞	Syk	1 nM
S125098	Sorafenib	≥99%	284461-73-0	250mg,1g	无细胞	Raf-1	6 nM
					无细胞	B-Raf	22 nM
						VEGFR-2	90 nM
						VEGFR-3	20 nM
						PDGFR-β	57 nM
						Flt-3	59 nM
						c-KIT	68 nM
C129757	Cabozantinib malate (XL184)	≥99%	1140909-48-3	10mg,25mg,50mg,100mg,250mg		VEGFR2	0.035 nM
					无细胞	c-Met	1.3 nM
						Ret	4 nM
						Kit	4.6 nM
						Flt-1/3/4	12 nM/11.3 nM/6 nM
						Tie2	14.3 nM
						AXL	7 nM
T129806	TCS 359	≥99%	301305-73-7	10mg,25mg,50mg		FLT3	43 nM
E129946	ENMD-2076 L-(+)-Tartaric acid	≥99%	1291074-87-7	5mg,25mg		Aurora A	14 nM
E129946	ENMD-2076 L-(+)-Tartaric acid	≥99%	1291074-87-7	5mg,25mg		VEGFR(Flt3)	1.86 nM
L127298	LY2801653	-	1206799-15-6	5mg,10mg,50mg		MET		2 nM
C168062	Crotonoside	95% (HPLC)	1818-71-9	5mg,10mg,25mg		FLT3
C168062	Crotonoside	95% (HPLC)	1818-71-9	5mg,10mg,25mg		HDAC3/6
G172979	Gilteritinib	97%	1254053-43-4	5mg,100mg		FLT3	0.29 nM
G172979	Gilteritinib	97%	1254053-43-4	5mg,100mg		AXL	0.73 nM
P171724	Pexidartinib	97%	1029044-16-3	5mg,100mg		CSF-1R	20 nM
						Kit	10 nM
						FLT3	160 nM

*DNA alkylator

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	EC50	Ki
S129593	Sorafenib Tosylate	≥99%	475207-59-1	10mg,50mg,250mg,1g,5g	无细胞	Raf-1	6 nM
					无细胞	B-Raf	22 nM
						VEGFR-2	90 nM
						VEGFR-3	20 nM
						PDGFR-β	57 nM
						Flt-3	59 nM
						c-KIT	68 nM
E129728	Sunitinib Malate	≥99%	341031-54-7	100mg,500mg,1g	无细胞	VEGFR2 (Flk-1)	80 nM
E129728	Sunitinib Malate	≥99%	341031-54-7	100mg,500mg,1g	无细胞	PDGFRβ	2 nM
L125046	Lenalidomide	≥99%	191732-72-6	50mg,250mg,1g,5g	PBMCs	TNF-α	13 nM
C126195	Cabozantinib (XL184, BMS-907351)	≥98%	849217-68-1	5mg,10mg,50mg,100mg,250mg	无细胞	VEGFR2	0.035 nM
						c-Met	1.3 nM
						Ret	4 nM
						Kit	4.6 nM
						Flt-1/3/4	12 nM/11.3 nM/6 nM
						Tie2	14.3 nM
						AXL	7 nM
P127550	Ponatinib (AP24534)	≥99%	943319-70-8	10mg,50mg,250mg	无细胞	Abl	0.37 nM
						PDGFRα	1.1 nM
						VEGFR2	1.5 nM
						FGFR1	2.2 nM
						Src	5.4 nM
K125585	Ki20227	≥98%	623142-96-1	10mg,50mg		KDR	2 nM
						VEGFR-2	12 nM
						c-Kit	451 nM
						PDGFRβ	217 nM
A129732	Axitinib	≥99%	319460-85-0	10mg,50mg,250mg,1g	猪主动脉内皮细胞	VEGFR1	0.1 nM
						VEGFR2	0.2 nM
						VEGFR3	0.1-0.3 nM
						PDGFRβ	1.6 nM
						c-Kit	1.7 nM
F127011	Foretinib (GSK1363089)	≥98%	849217-64-7	5mg,25mg,100mg	无细胞	Met	0.4 nM
F127011	Foretinib (GSK1363089)	≥98%	849217-64-7	5mg,25mg,100mg	无细胞	KDR	0.9 nM
N129725	Nintedanib (BIBF 1120)	≥98%	656247-17-5	5mg,10mg,25mg,50mg,100mg,500mg	无细胞	VEGFR1	34 nM
						VEGFR2	13 nM
						VEGFR3	13 nM
						FGFR1	69 nM
						FGFR2	37 nM
						FGFR3	108 nM
						PDGFRα	59 nM
						PDGFRβ	65 nM
V125180	Vandetanib (ZD6474)	≥99%	443913-73-3	25mg,100mg,500mg	无细胞	VEGFR2	40 nM
						VEGFR3	110 nM
						EGFR	500 nM
R127804	Regorafenib (BAY 73-4506)	≥99%	755037-03-7	5mg,10mg,25mg,100mg	无细胞	VEGFR1	13 nM
						VEGFR2	4.2 nM
						VEGFR3	46 nM
						PDGFR-β	22 nM
						Kit	7 nM
						RET	1.5 nM
						Raf-1	2.5 nM
P129722	Pazopanib HCl (GW786034 HCl)	≥98%	635702-64-6	25mg,100mg,250mg,1g	无细胞	VEGFR1	10 nM
						VEGFR2	30 nM
						VEGFR3	47 nM
						PDGFR	84 nM
						FGFR	74 nM
						c-Kit	140 nM
						c-fms	146 nM
C125911	Cediranib	≥98%	288383-20-0	10mg,50mg		VEGFR(KDR)	<1 nM
C125911	Cediranib	≥98%	288383-20-0	10mg,50mg		Flt1/4	5 nM/≤3 nM
P125865	PD173074	≥99%	219580-11-7	5mg,10mg,50mg		FGFR1	25 nM
P125865	PD173074	≥99%	219580-11-7	5mg,10mg,50mg		VEGFR2	100-200 nM
D126778	Dovitinib (TKI-258, CHIR-258)	≥99%	405169-16-6	10mg,50mg,250mg	无细胞	FLT3	1 nM
D126778	Dovitinib (TKI-258, CHIR-258)	≥99%	405169-16-6	10mg,50mg,250mg	无细胞	c-Kit	2 nM
L126993	Linifanib (ABT-869)	≥99%	796967-16-3	5mg,10mg,50mg		KDR	4 nM
						CSF-1R	3 nM
						Flt-1/3	3 nM/4 nM
						PDGFRβ	66 nM
V125857	Vatalanib (PTK787) 2HCl	≥99%	212141-51-0	10mg,50mg	无细胞	VEGFR2/KDR	37 nM
R127906	RAF265 (CHIR-265)	≥98%	927880-90-8	1mg,5mg,10mg,50mg		VEGFR2		30 nM
R127906	RAF265 (CHIR-265)	≥98%	927880-90-8	1mg,5mg,10mg,50mg		B-Raf	3-60 nM
T126012	Tivozanib (AV-951)	≥98%	475108-18-0	5mg,25mg,100mg		VEGFR1	0.21 nM
						VEGFR2	0.16 nM
						VEGFR3	0.24 nM
M129736	Motesanib Diphosphate (AMG-706)	≥98%	857876-30-3	5mg,10mg,50mg		VEGFR1	2 nM
						VEGFR2	3 nM
						VEGFR3	6 nM
L125518	Lenvatinib (E7080)	≥99%	417716-92-8	5mg,10mg,50mg,100mg		VEGFR2(KDR)	4 nM
L125518	Lenvatinib (E7080)	≥99%	417716-92-8	5mg,10mg,50mg,100mg		VEGFR3(Flt-4)	5.2 nM
B127317	Brivanib (BMS-540215)	≥98%	649735-46-6	5mg,10mg,50mg		VEGFR2	25 nM
M127064	MGCD-265	≥98%	875337-44-3	1mg,5mg,10mg,50mg		c-Met	1 nM
M127064	MGCD-265	≥98%	875337-44-3	1mg,5mg,10mg,50mg		VEGFR1/2/3	3 nM/3 nM/4 nM
A126830	AEE788 (NVP-AEE788)	≥97%	497839-62-0	5mg,25mg,100mg		EGFR	2 nM
A126830	AEE788 (NVP-AEE788)	≥97%	497839-62-0	5mg,25mg,100mg		HER2/ErbB2	6 nM
E126318	ENMD-2076	≥99%	934353-76-1	5mg,10mg,50mg		Aurora A	14 nM
E126318	ENMD-2076	≥99%	934353-76-1	5mg,10mg,50mg		Flt3	1.86 nM
O126155	OSI-930	≥99%	728033-96-3	1mg,5mg,25mg,50mg		Kit	80 nM
						KDR	9 nM
						CSF-1R	15 nM
C126929	CYC116	≥99%	693228-63-6	1mg,10mg,50mg		Aurora A			8.0 nM
						Aurora B			9.2 nM
						VEGFR2			44 nM
K125876	Ki8751	≥98%	228559-41-9	5mg,25mg,100mg		VEGFR2	0.9 nM
T129747	Telatinib	≥99%	332012-40-5	1mg,5mg,10mg,50mg		VEGFR2/3	6 nM/4 nM
						c-Kit	1 nM
						PDGFRα	15 nM
P126419	PP121	≥98%	1092788-83-4	10mg,50mg		PDGFR	2 nM
						Hck	8 nM
						mTOR	10 nM
						VEGFR2	12 nM
						Src	14 nM
						Abl	18 nM
						DNA-PK	60 nM
P125184	Pazopanib	≥99%	444731-52-6	25mg,100mg,500mg		GFR1	10 nM
						VEGFR2	30 nM
						VEGFR3	47 nM
						PDGFR	84 nM
						FGFR	74 nM
						c-Kit	140 nM
						c-Fms/CSF1R	146 nM
K125907	KRN-633	≥97%	286370-15-8	5mg,25mg,100mg		VEGFR1	170 nM
						VEGFR2	160 nM
						VEGFR3	125 nM
S126571	SAR131675	≥99%	1433953-83-3	1mg,10mg,50mg		VEGFR3	23 nM		12 nM
B129768	BMS-794833	≥99%	1174046-72-0	1mg,5mg,10mg,50mg		Met	1.7 nM
B129768	BMS-794833	≥99%	1174046-72-0	1mg,5mg,10mg,50mg		VEGFR2	15 nM
S125098	Sorafenib	≥99%	284461-73-0	250mg,1g	无细胞	Raf-1	6 nM
					无细胞	B-Raf	22 nM
						VEGFR-2	90 nM
						VEGFR-3	20 nM
						PDGFR-β	57 nM
						Flt-3	59 nM
						c-KIT	68 nM
C129757	Cabozantinib malate (XL184)	≥99%	1140909-48-3	10mg,25mg,50mg,100mg,250mg		VEGFR2	0.035 nM
						c-Met	1.3 nM
						Ret	4 nM
						Kit	4.6 nM
						Flt-1/3/4	12 nM/11.3 nM/6 nM
						Tie2	14.3 nM
						AXL	7 nM
B129764	Brivanib Alaninate (BMS-582664)	≥95%	649735-63-7	10mg,50mg		VEGFR2	25 nM
E126304	Golvatinib (E7050)	≥99%	928037-13-2	1mg,5mg,10mg,50mg		c-Met	14 nM
E126304	Golvatinib (E7050)	≥99%	928037-13-2	1mg,5mg,10mg,50mg		VEGFR-2	16 nM
Z129748	ZM 306416	≥98%	690206-97-4	10mg,50mg		VEGFR1	0.33 μM
Z129748	ZM 306416	≥98%	690206-97-4	10mg,50mg		EGFR	<10 nM
Z129761	ZM 323881 HCl	≥99%	193000-39-4	1mg,10mg,50mg		VEGFR2	<2 nM
E129946	ENMD-2076 L-(+)-Tartaric acid	≥99%	1291074-87-7	5mg,25mg		Aurora A	14 nM
E129946	ENMD-2076 L-(+)-Tartaric acid	≥99%	1291074-87-7	5mg,25mg		VEGFR(Flt3)	1.86 nM
L126507	LY2874455	≥99%	1254473-64-7	5mg,10mg,50mg		FGFR1	2.8 nM
						FGFR2	2.6 nM
						FGFR3	6.4 nM
						FGFR4	6 nM
						VEGFR2	7 nM
S167823	SU1498	98% (HPLC)	168835-82-3	5mg,25mg		KDR	0.7 μM
D126474	DCC-2618	-	1225278-16-9	5mg,10mg,50mg
S126061	苏尼替尼	0.99	557795-19-4	100mg,500mg,1g,5g,25g		VEGFR2(Flk-1)	80 nM
S126061	苏尼替尼	0.99	557795-19-4	100mg,500mg,1g,5g,25g		PDGFRβ	2 nM
D167318	2-D08	98% (HPLC)	144707-18-6	5mg,25mg		Axl	0.49 nM
						IRAK4	3.9 nM
						ROS1	5.3 nM
						MLK4	9.8 nM
						GSK3β	11 nM
						RET	11 nM
						KDR	17 nM
						PI3Kα	35 nM

*BTK

产品号	产品名称	规格	CAS	包装	靶点	IC50
P127143	Ibrutinib (PCI-32765)	≥98%	936563-96-1	5mg,10mg,50mg,250mg	BTK	0.5 nM
A127694	AVL-292	98%	1202757-89-8	5mg,10mg,50mg,100mg	BTK	0.5 nM
O173511	Olmutinib	97%	1353550-13-6	5mg,100mg

*PDGFR

KDR0.86 nM

产品号	产品名称	规格	CAS	包装	细胞	靶点	IC50
S129593	Sorafenib Tosylate	≥99%	475207-59-1	50mg,100mg,250mg,1g,5g	无细胞	Raf-1	6 nM
						VEGFR2/Flk1	15 nM
					无细胞	B-Raf	22 nM
						B-Raf (V599E)	38 nM
						PDGFRβ	57 nM
						mPDGFRβ	57 nM
						FLT3	58 nM
						c-Kit	68 nM
						VEGFR2	90 nM
						FGFR1	580 nM
I129225	Imatinib Mesylate (STI571)	≥99%	220127-57-1	100mg,250mg,1g,5g,25g	无细胞	PDGFR	100 nM
						c-Kit	100 nM
						v-Abl	600 nM
E129728	Sunitinib Malate	≥99%	341031-54-7	100mg,500mg,1g	无细胞	PDGFRβ	2 nM
					无细胞	VEGFR2	80 nM
						FLT3
						Kit
P127550	Ponatinib (AP24534)	≥99%	943319-70-8	10mg,250mg,50mg	无细胞	Abl	0.37 nM
						PDGFRα	1.1 nM
						VEGFR2	1.5 nM
						FGFR1	2.2 nM
						c-Src	5.4 nM
						c-Kit	12.5 nM
A129732	Axitinib	≥99%	319460-85-0	10mg,250mg,50mg,1g		VEGFR1/FLT1	0.1 nM
						VEGFR2/Flk1	0.18 nM
						VEGFR2/KDR	0.2 nM
						VEGFR3	0.1 nM-0.3 nM
						PDGFRβ	1.6 nM
						Kit	1.7 nM
						PDGFRα	5.0 nM
I124963	Imatinib (STI571)	≥99%	152459-95-5	1g,5g,25g,250mg		PDGFR	100 nM
						c-Kit	100 nM
						v-Abl	600 nM
F127011	Foretinib (GSK1363089)	≥99%	849217-64-7	5mg,100mg,25mg	无细胞	Met	0.4 nM
					无细胞		Tie-2	1.1 nM
					VEGFR3/FLT4		2.8 nM
					RON		3 nM
					FLT3		3.6 nM
					PDGFRα		3.6 nM
					Kit		6.7 nM
					VEGFR1/FLT1		6.8 nM
					PDGFRβ		9.6 nM

*Src

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50
D125110	Dasatinib	≥99%	302962-49-8	25mg,100mg,500mg,1g,5g	无细胞	Abl	0.6 nM
						Src	0.8 nM
						c-Kit (D816V)	37 nM
						c-Kit (wt)	79 nM
P127550	Ponatinib (AP24534)	≥99%	943319-70-8	10mg,50mg,250mg	无细胞	Abl	0.37 nM
						PDGFRα	1.1 nM
						VEGFR2	1.5 nM
						FGFR1	2.2 nM
						c-Src	5.4 nM
						c-Kit	12.5 nM
B129905	Bosutinib (SKI-606)	≥99%	380843-75-4	10mg,50mg,100mg		S6 kinase
						ERK
						STAT3
					无细胞	Abl	1 nM
					无细胞	Src	1.2 nM
P125444	Pelitinib	≥98%	257933-82-7	5mg,25mg,100mg		EGFR	38.5 nM
						Src	282 nM
						MEK/ERK	800 nM
						ErbB2	1.255 μM
						Raf	3.353 μM
K126255	KX2-391	≥99%	897016-82-9	1mg,5mg,10mg,50mg		Src (HuH7)	9 nM
						Src (PLC/PRF/5)	13 nM
						Src (Hep 3B)	26 nM
						Src (Hep G2)	60 nM
N127928	NVP-BHG712	≥98%	940310-85-0	5mg,25mg,100mg		EphB4	25 nM(ED50)
						C-Raf	0.395 μM
						c-Src	1.266 μM
						c-Abl	1.667 μM
E126318	ENMD-2076	≥99%	934353-76-1	5mg,10mg,50mg		FLT3	1.86 nM
						RET	10.4 nM
						Aurora A	14 nM
						VEGFR3/FLT4	15.9 nM
						Src	20.2 nM
						NTRK1/TRKA	24.2 nM
						CSF-1R/c-Fms	24.8 nM
						LCK	43.7 nM
						FAK	54.9 nM
						PDGFRα	56.4 nM
						VEGFR2/KDR	58.2 nM
						BLK	69.4 nM
						FGFR2	70.8 nM
						YES1	78.4 nM
						Abl1 (T315I)	81.3 nM
						FGFR1	92.7 nM
						Fyn	112 nM
						JAK2	120 nM
						Kit	120 nM
						Aurora B	350 nM
P129908	PRT062607 (P505-15, BIIB057) HCl	≥98%	1370261-97-4	5mg,25mg,	无细胞	Syk	1 nM
						FGR	81 nM
						MLK1	88 nM
						PYK2	108 nM
						YES	123 nM
						FLT3	139 nM
						PAK5	166 nM
						Lyn	192 nM
						cSRC	244 nM
						LCK	249 nM
						FAK	415 nM
P125361	PP2	≥98%	172889-27-9	5mg,25mg,100mg	无细胞	LCK	4 nM
P125361	PP2	≥98%	172889-27-9	5mg,25mg,100mg	无细胞	Fyn	5 nM
P126419	PP121	≥98%	1092788-83-4	10mg,50mg		PDGFR	2 nM
						Hck	8 nM
						VEGFR	12 nM
						mTOR	13 nM
						Src	14 nM
						Abl	18 nM
						p110α	52 nM
						DNA-PK	60 nM
						p110δ	150 nM
						EphB4	190 nM
Q111274	槲皮素	95.00%	117-39-5	1g,10g,50g,250g		Sirtuin
						Src
						PKC
						PI3Kγ	2.4 μM
						PI3Kδ	3.0 μM
						PI3Kβ	5.4 μM
Q111273	槲皮素	分析标准品,≥98.5%	117-39-5	20mg		Sirtuin
						Src
						PKC
						PI3Kγ	2.4 μM
						PI3Kδ	3.0 μM
						PI3Kβ	5.4 μM

*Syk

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50
R129913	R788 (Fostamatinib) Disodium	≥98%	1025687-58-4	50mg,1mg,5mg,10mg	无细胞	Syk	41 nM
R129910	R406 (free base)	≥99%	841290-80-0	25mg,50mg,100mg,5mg,10mg	无细胞	Syk	41 nM
R129910	R406 (free base)	≥99%	841290-80-0	25mg,50mg,100mg,5mg,10mg	无细胞	FLT3
P129908	PRT062607 (P505-15, BIIB057) HCl	≥98%	1370261-97-4	5mg,25mg	无细胞	Syk	1 nM
						FGR	81 nM
						MLK1	88 nM
						PYK2	108 nM
						YES	123 nM
						FLT3	139 nM
						PAK5	166 nM
						Lyn	192 nM
						cSRC	244 nM
						LCK	249 nM
						FAK	415 nM
F129915	Fostamatinib (R788)	≥98%	901119-35-5	50mg,5mg,10mg		Syk	41 nM
						Adenosine A3 receptor	81 nM
						Adenosine transporter	1.84 μM
						Monoamine transporter	2.74 μM

*VDA

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	Ki
D129922	DMXAA (Vadimezan)	≥98%	117570-53-3	5mg,25mg,100mg,250mg	无细胞	DT-diaphorase	62.5 μM	20 μM
P126141	Plinabulin (NPI-2358)	≥97%	714272-27-2	5mg,10mg,50mg,1g	肿瘤细胞	Tubulin	9.8~18 nM
V129759	Verteporfin	≥97%	129497-78-5	25mg,50mg,1mg,5mg,10mg		VDA
V129759	Verteporfin	≥97%	129497-78-5	25mg,50mg,1mg,5mg,10mg		YAP/TEAD interaction

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