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阿拉丁小分子抑制剂、激动剂、拮抗剂---神经信号通路
2020-10-13
神经信号
神经信号参与中枢神经系统的结构、功能、遗传和生理的调节。神经元合成/导入神经递质，并将其储存在突触前囊泡中。突触前神经元释放的小泡，进而传递神经冲动。常见的神经递质有γ氨基丁酸（GABA）、谷氨酸、血清素、多巴胺等。在神经信号通路中，这些神经递质的功能障碍可能多种神经系统疾病，如慢性疼痛、神经退行性疾病、失眠、精神障碍（精神分裂症、双相情感障碍、抑郁症和成瘾）等。
神经信号通路转导过程
当受到来自环境或其他神经元的信号刺激时，神经递质受体通过G蛋白偶联信号通路和G蛋白非依赖机制激活下游细胞内信号通路：包括cAMP/PKA, PI3K/AKT, 磷脂酶A2（PLA2）, 磷脂酶C（PLC）信号通路等。例如，多巴胺受体通过cAMP激活PKA等信号分子，通过CREB和其他转录因子的作用调控基因表达。其他神经递质如NMDAR或AMPAR与控制Ca2+和Na+流量的离子通道有关，这样就能在突触后神经元中传递动作电位。
神经信号通路图
产品列表
*Aβ
| 项目号 | 产品名称 | 规格 | CAS | 包装 | 细胞 | 靶点 | IC50 | EC50 |
|---|---|---|---|---|---|---|---|---|
| D126677 | DAPT | ≥98% | 208255-80-5 | 5mg,10mg,25mg,50mg | HEK 293细胞 | γ-secretase | 20 nM | |
| R127403 | RO4929097 | ≥99% | 847925-91-1 | 5mg,10mg,50mg | 无细胞 | γ secretase | 4 nM | |
| Aβ40 | 14 nM | |||||||
| Notch | 5 nM | |||||||
| M126008 | MK-0752 | ≥99% | 471905-41-6 | 5mg,10mg,50mg | γ-secretase | 5 nM | ||
| B126453 | Avagacestat (BMS-708163) | ≥99% | 1146699-66-2 | 5mg,10mg,50mg | Aβ40 | 0.3 nM | ||
| Aβ42 | 0.27 nM | |||||||
| L128069 | LY2811376 | ≥99% | 1194044-20-6 | 5mg,10mg,50mg | BACE1 | 239 nM-249 nM | ||
| Aβ | 300 nM | |||||||
| H108813 | 2-羟丙基-β-环糊精 | 97% | 128446-35-5 | 5g,25g,100g,250g | amyloid-β aggregation |
*5-HT受体
| 项目号 | 产品名称 | 规格 | CAS | 包装 | 细胞 | 靶点 | IC50 | Ki | ED50 | pKi |
|---|---|---|---|---|---|---|---|---|---|---|
| F131623 | Fluoxetine HCl | ≥98%(HPLC) | 56296-78-7 | 1g,5g,25g | 5-HT | |||||
| V129637 | Venlafaxine hydrochloride | ≥98% (HPLC) | 99300-78-4 | 1g,5g,25g,100g | 5-HT | |||||
| D129639 | Dapoxetine hydrochloride | ≥98% (HPLC) | 129938-20-1 | 250mg,1g,5g | 5-HT | |||||
| I125279 | Iloperidone | ≥98% | 133454-47-4 | 50mg,250mg,1g,5g | 5-HT | |||||
| V129787 | Vortioxetine (Lu AA21004) HBr | ≥98% | 960203-27-4 | 5mg,25mg,100mg | 5-HT1A | 15 nM | ||||
| 5-HT1B | 33 nM | |||||||||
| 5-HT3A | 3.7 nM | |||||||||
| 5-HT7 | 19 nM | |||||||||
| SERT | 1.6 nM | |||||||||
| F129671 | Fluvoxamine maleate | ≥98% | 61718-82-9 | 250mg,1g,5g,25g,100g | 5-HT | |||||
| S129789 | Sertraline HCl | ≥98% (HPLC) | 79559-97-0 | 1g,5g | 5-HT | 13 nM | ||||
| L129555 | Lamotrigine | ≥98% | 84057-84-1 | 1g,5g | 人类血小板 | 5-HT | 240 μM | |||
| 大鼠脑突触体 | 5-HT | 474 μM | ||||||||
| C129687 | Clomipramine HCl | ≥99% | 17321-77-6 | 1g,5g,25g | SERT | 0.14 nM | ||||
| NET | 54 nM | |||||||||
| DAT | 3 nM | |||||||||
| E122736 | 草酸右旋西酞普兰 | 98% | 219861-08-2 | 50mg,250mg,1g,5g | 5-HT | 0.89 nM | ||||
| D123291 | 盐酸度洛西汀 | ≥98.0%(HPLC) | 136434-34-9 | 1g,5g,25g | 5-HT | 4.6 nM | ||||
| M129386 | Milnacipran hydrochloride | ≥99% | 101152-94-7 | 10mg,50mg,250mg,500mg,1g,5g,25g | NET | 77 nM | ||||
| SERT | 220 nM | |||||||||
| A129730 | 盐酸阿米替林 | ≥98% | 549-18-8 | 1g,5g,25g,100g | 5-羟色胺受体 | 3.45 nM | ||||
| 去甲肾上腺素受体 | 13.3 nM | |||||||||
| 5-HT4 | 7.31 nM | |||||||||
| 5-HT2 | 235 nM | |||||||||
| sigma 1受体 | 287 nM | |||||||||
| L174987 | Levomilnacipran hydrochloride | 97% | 175131-60-9 | 100mg,250mg,1g | ||||||
| D154262 | 3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸倍半水合物 | >98.0%(HPLC)(T) | 555-30-6 | 5g,25g,100g | DOPA decarboxylase | 21.8 mg/kg | ||||
| C122737 | 氢溴酸西酞 | 98% | 59729-32-7 | 1g,5g | serotonin reuptake | 1.8 nM | ||||
| V129637 | Venlafaxine hydrochloride | ≥98% (HPLC) | 93413-69-5 | 1g,5g,25g,100g | SNRI | |||||
| D136408 | 盐酸去甲咪嗪 | ≥98% | 58-28-6 | 1g,5g,25g | ||||||
| T129695 | 曲唑酮 盐酸盐 | 98% | 25332-39-2 | 1g | 5-HT | |||||
| P137447 | Protriptyline Hydrochloride | ≥98% | 1225-55-4 | 25mg,100mg | ||||||
| A129721 | Atomoxetine HCl | ≥98% | 82248-59-7 | 50mg,250mg,1g | Norepinephrine (NE) transporter | 5 nM | ||||
| C126883 | 氯氮平 | ≥98%(GC) | 5786-21-0 | 100mg,1g,5g,25g,100g | 5-HT | 110 nM | ||||
| O126519 | Olanzapine | ≥99% | 132539-06-1 | 1g,5g | 5-HT2 | |||||
| D2 receptor | ||||||||||
| K129651 | Ketanserin | ≥97% | 74050-98-9 | 50mg,250mg,1g | 5-HT2A | 2.5 nM | ||||
| 5-HT2C (Rat) | 50 nM | |||||||||
| 5-HT2C (Human) | 100 nM | |||||||||
| L129669 | Latrepirdine | ≥96% | 97657-92-6 | 5mg,10mg,50mg | GluR | |||||
| Histamine receptor | ||||||||||
| 5-HT | ||||||||||
| A129730 | 盐酸阿米替林 | ≥98% | 50-48-6 | 1g,5g,25g,100g | ||||||
| A124691 | 阿戈美拉汀 | ≥98%(HPLC) | 138112-76-2 | 5mg,25mg,50mg,250mg,1g,5g,25g | 5-HT2C | |||||
| A124739 | Asenapine maleate | ≥98% (HPLC) | 85650-56-2 | 10mg,50mg,250mg,1g | ||||||
| R127644 | Risperidone | ≥98% | 106266-06-2 | 500mg,5g,25g,100g | 5-HT2A | 0.17 nM | ||||
| α2c-adrenergic receptor | 1.3 nM | |||||||||
| D2 receptor | 3.57 nM | |||||||||
| D3 receptor | 3.6 nM | |||||||||
| D2L Receptor | 4.16 nM | |||||||||
| E129717 | Ziprasidone HCl | ≥98% | 122883-93-6 | 250mg,1g | 5-HT receptor | |||||
| Dopamine receptor | ||||||||||
| W129689 | WAY-100635 Maleate | ≥99% | 1092679-51-0 | 5mg,25mg,100mg | 5-HT | 0.95 nM | ||||
| B129706 | Blonanserin | ≥98% (HPLC) | 132810-10-7 | 25mg,100mg | 5-HT2 | 3.98 nM | ||||
| dopamine D2 receptor | 14.8 nM | |||||||||
| S125056 | SB269970 HCl | - | 261901-57-9 | 10mg | 5-HT7 | |||||
| S129658 | SB269970 HCl | ≥99% | 261901-57-9 | 10mg,50mg | 5-HT7 | |||||
| G120176 | 盐酸格拉司琼 | 98% | 107007-99-8 | 10mg,50mg,1g,5g | 5-HT3 | |||||
| M129297 | Mirtazapine | ≥98% | 85650-52-8 | 100mg,1g | 5-HT | |||||
| S127746 | SB742457 | ≥97% | 607742-69-8 | 5mg,25mg | 5-HT6 | |||||
| B129690 | BRL-15572 | ≥99% | 193611-72-2 | 5mg,10mg,50mg | 5-HT1D | 7.9 | ||||
| 5-HT1A | 7.7 | |||||||||
| 5-HT2B | 7.4 | |||||||||
| 5-HT2A | 6.6 | |||||||||
| 5-HT7 | 6.3 | |||||||||
| P129785 | PRX-08066 Maleic acid | ≥99% | 866206-55-5 | 5mg,10mg,50mg | 5-HT2B | 3.4 nM | ||||
| T124762 | 盐酸托烷司琼 | ≥98.0% | 105826-92-4 | 250mg,1g,5g | 5-HT3 | |||||
| P129438 | Pizotifen Malate | ≥99% | 5189-11-7 | 100mg,500mg | ||||||
| A129701 | Azasetron HCl | ≥99% | 123040-16-4 | 25mg,100mg | 5-HT3 | 0.33 nM | ||||
| F129636 | 夫洛丙酮 | ≥99% | 2295-58-1 | 50mg | 5-HT1A | |||||
| O129694 | Ondansetron | ≥99% | 99614-02-5 | 10mg,50mg,250mg | 5-HT3 | |||||
| P129744 | Palonosetron HCl | ≥99% | 135729-62-3 | 100mg,500mg | 5-HT3 | |||||
| V129763 | VUF 10166 | ≥99% | 155584-74-0 | 10mg,50mg,250mg | 5-HT3A | 0.04 nM | ||||
| 5-HT3AB | 22 nM | |||||||||
| N159830 | 奈法唑酮盐酸盐 | 99% | 82752-99-6 | 200mg,1g | ||||||
| C101491 | 盐酸赛庚啶 | 98% | 41354-29-4 | 1g,5g,25g | 5-HT2 | 0.6 nM | ||||
| SETD7/9 | 1 μM | |||||||||
| O129679 | Ondansetron Hydrochloride Dihydrate | ≥98% (HPLC) | 103639-04-9 | 1g,5g | 5-HT3 receptor | 6.16 nM | ||||
| A135530 | Alosetron Hydrochloride | ≥98% (HPLC) | 122852-69-1 | 1g,5g | 5-HT3 receptor | |||||
| S132232 | Sarpogrelate Hydrochloride | ≥98% | 135159-51-2 | 5mg,25mg,100mg | 5-HT2A | 8.52 | ||||
| 5-HT2B | 6.57 | |||||||||
| 5-HT2C | 7.43 | |||||||||
| R166990 | Ramosetron hydrochloride | 98% (HPLC) | 132907-72-3 | 10mg,50mg,100mg,250mg | 5-HT3 receptor | 0.091 nM | ||||
| P111269 | 葛根素 | 分析标准品,≥98% | 3681-99-0 | 20mg | 5-HT2C | |||||
| P111270 | 葛根素 | 98% | 3681-99-0 | 1g,5g,25g,100g | 5-HT2C | |||||
| T124762 | 盐酸托烷司琼 | ≥98.0% | 89565-68-4 | 250mg,1g,5g | 5-HT3 receptor | 5.3 nM | ||||
| α7 nAChR | 6.9 nM | |||||||||
| C134704 | Cyclobenzaprine hydrochloride | 98% | 6202-23-9 | 1g,5g,25g | 5-HT2 receptor | |||||
| G127257 | Granisetron | - | 109889-09-0 | 25mg,50mg,100mg,250mg | 5HT-3 | |||||
| L129692 | LY310762 | ≥95% | 192927-92-7 | 10mg,50mg | 5-HT1D | 249 nM | ||||
| P125293 | Palonosetron | - | 135729-61-2 | 10mg,100mg | 5-HT3 receptor | 0.17 nM | ||||
| M124574 | 5-甲氧基色胺 | 97% | 608-07-1 | 250mg,1g,5g,25g | 5-HT1 | |||||
| 5-HT2 | ||||||||||
| 5-HT4 | ||||||||||
| 5-HT6 | ||||||||||
| 5-HT7 | ||||||||||
| T162853 | Tianeptine sodium salt hydrate | >98.0%(HPLC) | 30123-17-2 | 200mg,1g,5g | 5-HT | |||||
| S129681 | Sumatriptan Succinate | ≥98% (HPLC) | 103628-48-4 | 50mg,100mg,250mg,1g | 5-HT | |||||
| P129662 | Prucalopride | ≥99% | 179474-81-8 | 10mg,50mg | 5-HT4A | 2.5 nM | ||||
| 5-HT4B | 8 nM | |||||||||
| A124880 | Aripiprazole | ≥99% | 129722-12-9 | 1g,5g | 5-HT1A | 4.2 nM | ||||
| N129630 | Naratriptan hydrochloride | ≥98% | 143388-64-1 | 10mg,25mg,50mg,100mg | 5-HT | |||||
| R129638 | Rizatriptan Benzoate | ≥98%(HPLC) | 145202-66-0 | 10mg,50mg,250mg,1g,5g | 5-HT1 | |||||
| Z129649 | Zolmitriptan | ≥98%(HPLC) | 139264-17-8 | 200mg,250mg, | 5-HT | |||||
| M129673 | Mosapride Citrate | ≥98% | 112885-42-4 | 10mg,50mg,250mg,1g,5g,25g | 5-HT4 | |||||
| E129729 | Eletriptan HBr | ≥98% | 177834-92-3 | 10mg,50mg,250mg,1g,5g | SSRI | |||||
| 5-HT1A | ||||||||||
| A129703 | Almotriptan Malate | ≥99% | 181183-52-8 | 1g | 5-HT1B | |||||
| 5-HT1D | ||||||||||
| T168187 | Tegaserod maleate | 98% (HPLC) | 189188-57-6 | 10mg,50mg | 5-HT4 receptor | |||||
| B129734 | BRL-54443 | ≥98% | 57477-39-1 | 10mg,50mg,100mg | 5-HT1A | 7.2 | ||||
| 5-HT1B | 6.9 | |||||||||
| 5-HT1D | 7.2 | |||||||||
| 5-HT1E | 8.7 | |||||||||
| 5-HT1F | 9.25 | |||||||||
| B178171 | brexpiprazole | 97% | 913611-97-9 | 1g | 5-HT1A | 0.12 nM | ||||
| D2L | 0.3 nM | |||||||||
| 5-HT1A | 0.12 nM | |||||||||
| 5-HT2A | 0.47 nM | |||||||||
| α1B受体 | 0.17 nM | |||||||||
| α2C受体 | 0.59 nM | |||||||||
| M179481 | Mosapride | 95% | 112885-41-3 | 1g,5g | 5HT4 | |||||
| S111161 | 血清胺盐酸盐 | AR | 153-98-0 | 1g,5g,25g | 5-HT | |||||
| V124992 | Vilazodone | ≥98% | 163521-12-8 | 10mg,50mg | ||||||
| F167802 | Flibanserin | 98% (HPLC) | 167933-07-5 | 5mg,25mg | 5-HT1A | 1 nM | ||||
| 5-HT2A | 49 nM | |||||||||
| D4 receptor | 4-24 nM | |||||||||
| V125545 | Vortioxetine | ≥98% | 508233-74-7 | 10mg,50mg,250mg,1g | ||||||
| P129402 | Azacyclonol | ≥99% | 115-46-8 | 50mg |
*COX
| 项目号 | 产品名称 | 规格 | CAS | 包装 | 细胞 | 靶点 | IC50 | EC50 | Ki |
|---|---|---|---|---|---|---|---|---|---|
| C129279 | Celecoxib | ≥99% | 169590-42-5 | 100mg,1g,5g,25g,100g | Sf9细胞 | COX-2 | 40 nM | ||
| N127367 | Nepafenac | ≥99% | 78281-72-8 | 250mg,1g,5g | COX1 | ||||
| COX2 | |||||||||
| I129291 | Ibuprofen | ≥98%(GC) | 15687-27-1 | 5g,25g,100g,250g,500g | COX-1 | 13 μM | |||
| COX-2 | 370 μM | ||||||||
| I106885 | 吲哚美辛 | 99% | 53-86-1 | 5g,25g,100g,500g | COX1 | 0.28 μM | |||
| COX2 | 14 μM | ||||||||
| S125148 | Sulindac | ≥98% | 38194-50-2 | 1g,5g,25g,100g | COX | ||||
| D155733 | Diclofenac | >98.0% | 15307-86-5 | 1g,5g,25g,100g | COX-1 | ||||
| COX-2 | |||||||||
| R126597 | Rofecoxib | ≥98% | 162011-90-7 | 50mg,250mg | COX-2 | 18 nM | |||
| M129228 | Meloxicam | ≥98% | 71125-38-7 | 5g,10g,25g,100g | |||||
| D129705 | 地塞米松磷酸钠 | ≥99% | 55203-24-2 | 50mg,250mg | IL receptor | ||||
| B129286 | Bufexamac | ≥98.0%(HPLC) | 2438-72-4 | 5g,25g | IFN-α | 8.9 μM | |||
| A104180 | 乙酰水杨酸 | 99% | 50-78-2 | 25g,100g,500g,2.5kg | COX1 | ||||
| COX2 | |||||||||
| A118582 | 乙酰水杨酸 | 用于植物细胞培养, ≥99.0% | 50-78-2 | 250g | COX1 | ||||
| COX2 | |||||||||
| S129974 | Suprofen | ≥99% | 40828-46-4 | 10mg,50mg | COX-1 | ||||
| COX-2 | |||||||||
| P129294 | Piroxicam | ≥98%(HPLC) | 36322-90-4 | 1g,5g,25g,100g | COX | ||||
| E129317 | Etodolac | ≥98% | 41340-25-4 | 1g,5g,25g,100g | COX | ||||
| K129331 | Ketoprofen | ≥98%(HPLC) | 22071-15-4 | 5g,25g,100g,250g,500g | COX-1 | ||||
| COX-2 | |||||||||
| D129332 | Diclofenac Sodium | ≥99% | 15307-79-6 | 5g,25g,100g,500g | COX-1 | 60 nM | |||
| COX-2 | 200 nM | ||||||||
| I129329 | Ibuprofen Lysine | ≥99% | 57469-77-9 | 20mg,100mg | COX | ||||
| L129341 | Lornoxicam | ≥98% (HPLC) | 70374-39-9 | 250mg,1g,5g | COX-1 | 5 nM | |||
| COX-2 | 8 nM | ||||||||
| K194835 | 酮咯酸 | 98% | 74103-06-3 | 250mg,1g,5g | COX-1 | 1.23 μM | |||
| COX-2 | 3.50 μM | ||||||||
| N129290 | Naproxen Sodium | ≥98% | 26159-34-2 | 5g,25g,100g | COX-1 | 8.7 μM | |||
| COX-2 | 5.2 μM | ||||||||
| L129349 | Lumiracoxib | ≥98% | 220991-20-8 | 50mg,250mg | COX-1 | 3 μM | |||
| COX-2 | 60 nM | ||||||||
| P129299 | Pranoprofen | ≥99% | 52549-17-4 | 1g,5g | COX | ||||
| Z129346 | Zaltoprofen | ≥98% | 74711-43-6 | 250mg,1g,5g,25g,100g | COX-1 | ||||
| COX-2 | |||||||||
| A129429 | Acemetacin | ≥98% | 53164-05-9 | 1g,5g,25g | COX | ||||
| T129337 | 托灭酸 | ≥98% | 13710-19-5 | 5g,25g,100g | COX-2 | 0.2 μM | |||
| V125795 | Valdecoxib | ≥99% | 181695-72-7 | 10mg,50mg,1g,5g | COX-2 | 5nM | |||
| P109420 | 非那西汀 | ≥98.0% (HPLC) | 62-44-2 | 25g,100g,500g | COX | ||||
| N159746 | Nimesulide | >98.0%(HPLC) | 51803-78-2 | 1g,5g,25g | COX-2 | 26 μM | |||
| A129507 | Amfenac Sodium Monohydrate | ≥99% | 61618-27-7 | 50mg,250mg,1g,5g,25g | COX-1 | 250 nM | |||
| COX-2 | 150 nM | ||||||||
| N129597 | 尼氟酸 | >98.0%(HPLC) | 4394-00-7 | 1g,5g,25g,100g | COX-2 | ||||
| A110659 | 安替比林 | CP,98% | 60-80-0 | 100g,500g | COX3 | ||||
| A110660 | 安替比林 | 99% | 60-80-0 | 100g,500g | COX3 | ||||
| A129352 | Ampiroxicam | ≥98% | 99464-64-9 | 50mg,250mg,1g | COX | ||||
| S161049 | Naproxen | >99.0% | 22204-53-1 | 5g,25g,100g,500g | COX-1 | ||||
| COX-2 | |||||||||
| B107666 | 次水杨酸铋 | 97% | 14882-18-9 | 100g,500g | COX1 | 20 nM | |||
| COX2 | 20 nM | ||||||||
| X139028 | (±)-磺吡酮 | ≥96% | 57-96-5 | 1g,5g | |||||
| C153919 | Carprofen | >98.0%(HPLC) | 53716-49-7 | 1g,5g,25g,100g | canine COX2 | 30 nM | |||
| D129411 | Diclofenac Diethylamine | ≥99% | 78213-16-8 | 5g,25g | COX1 | ||||
| COX2 | |||||||||
| D133115 | 二氟苯水杨酸 | ≥98% | 22494-42-4 | 1g,5g | COX | ||||
| P113217 | 菲尼酮 | 98.50% | 92-43-3 | 25g,100g,500g | COX | ||||
| LOX | |||||||||
| P113218 | 菲尼酮 | 97% | 92-43-3 | 100g,500g | COX | ||||
| LOX | |||||||||
| M157895 | 甲芬那酸 | >98.0% | 61-68-7 | 25g,100g,500g | COX-1 | ||||
| COX-2 | |||||||||
| E126660 | Etoricoxib | ≥98.0% | 202409-33-4 | 10mg,50mg,250mg,1g,5g | COX-2 | ||||
| S161351 | D-α-生育酚 | >97.0%(GC) | 59-02-9 | 25g,100g,500g | |||||
| O129611 | Oxaprozin | ≥98% | 21256-18-8 | 5g,25g,100g | COX-1 | ||||
| COX-2 | |||||||||
| R107337 | 吴茱萸次碱 | 分析标准品,≥98% | 84-26-4 | 10mg,20mg | COX2 | ||||
| R107338 | 吴茱萸次碱 | 98% | 84-26-4 | 50mg,250mg,1g | COX2 | ||||
| S104922 | D(-)-水杨苷 | 99% | 138-52-3 | 5g,25g,100g | COX1 | ||||
| S104923 | D(-)-水杨苷 | 分析标准品,≥99% | 138-52-3 | 20mg | COX1 | ||||
| S118533 | 水杨酸 | 用于植物细胞培养,≥99 % | 69-72-7 | 500g | |||||
| S104158 | 水杨酸 | AR,99.5% | 69-72-7 | 250g,1kg,2.5kg | |||||
| S104162 | 水杨酸 | ACS,≥99.0% | 69-72-7 | 250g,1kg | |||||
| X139169 | 黄腐酚 | ≥97.0%(HPLC) | 6754-58-1 | 5mg,25mg,100mg | |||||
| F121952 | Flunixin meglumine | 98% | 42461-84-7 | 250mg,1g,5g,25g |
*γ-secretase
| 项目号 | 产品名称 | 规格 | CAS | 包装 | 细胞 | 靶点 | IC50 |
|---|---|---|---|---|---|---|---|
| D126677 | DAPT | ≥98% | 208255-80-5 | 5mg,10mg,25mg,50mg | HEK 293细胞 | γ secretase(Aβ) | 20 nM |
| R127403 | RO4929097 | ≥99% | 847925-91-1 | 5mg,10mg,50mg | 无细胞 | γ secretase | 4 nM |
| Aβ40 | 14 nM | ||||||
| Notch | 5 nM | ||||||
| S125519 | Semagacestat (LY450139) | ≥98% | 425386-60-3 | 5mg,10mg,50mg | 人神经胶质瘤细胞 | Aβ42 | 10.9 nM |
| Aβ40 | 12.1 nM | ||||||
| Aβ38 | 12.0 nM | ||||||
| Notch | 14.1 nM | ||||||
| M126008 | MK-0752 | ≥99% | 471905-41-6 | 5mg,10mg,50mg | Aβ40 | 5 nM | |
| B126453 | Avagacestat (BMS-708163) | ≥99% | 1146699-66-2 | 5mg,10mg,50mg | Aβ40 | 0.3 nM | |
| Aβ42 | 0.27 nM | ||||||
| Y129283 | YO-01027 | ≥97% | 209984-56-5 | 2mg,5mg,25mg | 无细胞 | APPL | 2.6 nM |
| Notch | 2.9 nM | ||||||
| L125846 | LY-411575 | ≥98% | 209984-57-6 | 5mg,25mg,100mg | HEK293细胞 | APP | 0.078 nM |
| NΔE | 0.082 nM | ||||||
| Notch | 0.39 nM | ||||||
| P127448 | PF-3084014 | ≥98% | 1290543-63-3 | 5mg,10mg,25mg,50mg,100mg | 无细胞 | γ-secretase | 6.2 nM |
*GluR
| 项目号 | 产品名称 | 规格 | CAS | 包装 | 细胞 | 靶点 | IC50 | Ki | EC50 |
|---|---|---|---|---|---|---|---|---|---|
| X113958 | 黄尿酸 | 96% | 59-00-7 | 1g,5g | mGlu2 | ||||
| R129533 | Riluzole | ≥98% | 1744-22-5 | 1g,5g,25g,100g | mGlu3 | ||||
| L129669 | Latrepirdine | ≥96% | 97657-92-6 | 5mg,10mg,50mg | histamine receptors | ||||
| GluR | |||||||||
| 5-HT receptors | |||||||||
| C126237 | CTEP (RO4956371) | ≥99% | 871362-31-1 | 5mg,10mg,50mg | mGlu5 | 2.2 nM | |||
| M127959 | MPEP | ≥98% | 96206-92-7 | 10mg,50mg,250mg | mGluR5 | 36 nM | |||
| L127760 | LY404039 | ≥99% | 635318-11-5 | 5mg,25mg,50mg | mGlu2/mGlu3 | 149 nM | |||
| mGlu2/mGlu3 | 92 nM | ||||||||
| G103978 | L-谷氨酸 | 99% | 56-86-0 | 100g,250g,500g,2.5kg | |||||
| G103979 | L-谷氨酸 | 超纯级,≥99.5% (NT) | 56-86-0 | 100g,500g,2.5kg | |||||
| G107510 | L-谷氨酸 | 非动物源,EP,JP,USP ；用于细胞培养,98.5 to 101.0% | 56-86-0 | 100g,500g | |||||
| A129508 | ADX-47273 | ≥99% | 851881-60-2 | 5mg,10mg,50mg | mGlu5 | 0.17 μM | |||
| V129515 | VU 0357121 | ≥98% | 433967-28-3 | 10mg,50mg,250mg | mGluR5 | 30 nM | |||
| S161191 | L-O-磷酸丝氨酸 | >98.0%(T) | 407-41-0 | 1g,5g,25g | mGluR | ||||
| V129525 | VU 0364770 | ≥98% | 61350-00-3 | 10mg,50mg,250mg | mGlu4 | 1.1 μM | |||
| V129527 | VU 0361737 | ≥98%(HPLC) | 1161205-04-4 | 10mg,50mg,250mg | 人类受体 | mGluR4 | 240 nM | ||
| 大鼠受体 | mGluR4 | 110 nM | |||||||
| D107632 | D-谷氨酰胺 | 98% | 5959-95-5 | 1g,5g,25g,100g |
